Royal Devon University Healthcare NHS Foundation Trust was caring for 25 patients with coronavirus in hospital as of Sunday, figures show.
NHS England data shows the number of people being treated in hospital with Covid-19 by 8am on January 8 was up from 23 on the same day the previous week.
Across England, the number of hospital patients with Covid-19 has decreased by 35% in the last four weeks.
The figures also show that 20 new patients with Covid were admitted to hospital in Royal Devon University Healthcare NHS Foundation Trust in the week to May 8.